In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets
نویسندگان
چکیده
منابع مشابه
In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets
Alfuzosin, a selective alpha-1a antagonistis is the most recently approved AARAS, with limited cardiac toxicity and exclusively used for lower urinary tract syndromes (LUTS). In order to reduce pill burden and better patient compliance modified release (MR) formulations have been developed. Alfuzosin MR tablet was developed by the use of hot-melt granulation techniques using mono- and diglyceri...
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Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
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The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO) was used in tablets prepared by direct compression. The amounts of both polym...
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Due to complexity and interplay of variable gastrointestinal conditions with matrix tablets which are predominantly erosion controlled it is often difficult to predict in vivo release profile [1]. Nascent gel layer of matrix tablets is prone to mechanical stress which is difficult to simulate in vitro. Present study describes approaches to establish a biorelevant in vitro test for evaluation of...
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Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...
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ژورنال
عنوان ژورنال: ISRN Toxicology
سال: 2012
ISSN: 2090-6196
DOI: 10.5402/2012/813836